precoated silica gel plates (Miles Scientific)
86
Structured Review
Miles Scientific
precoated silica gel plates
Precoated Silica Gel Plates, supplied by Miles Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/precoated+silica+gel+plates/gel+plates+precoated+silica/pm42102182-16-8-12
Average 86 stars, based on 1 article reviews
Precoated Silica Gel Plates, supplied by Miles Scientific, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/precoated+silica+gel+plates/gel+plates+precoated+silica/pm42102182-16-8-12
Average 86 stars, based on 1 article reviews
precoated silica gel plates - by Bioz Stars,
2026-10
86/100 stars
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Thin Layer Chromatography:Article Title: Expedient Synthesis of Heterobifunctional Triarylmethane Stoppers for Macromolecular Rotaxanes. Article Snippet: Analytical TLC was performed on precoated silica gel plates (0.25 mm thick, 60 F254, Merck, Germany) and observed under UV light or stained with a phosphomolybdic acid solution. .. Preparative TLC was performed on Article Title: Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection. Article Snippet: Srikanth Venkatraman,* Stéphane L. Bogen, Ashok Arasappan, Frank Bennett, Kevin Chen, Edwin Jao, Yi-Tsung Liu, Raymond Lovey, Siska Hendrata, Yuhua Huang, Weidong Pan, Tejal Parekh, Patrick Pinto, Veljko Popov, Russel Pike, Sumei Ruan, Bama Santhanam, Bancha Vibulbhan, Wanli Wu, Weiying Yang, Jianshe Kong, Xiang Liang, Jesse Wong, Rong Liu, Nancy Butkiewicz, Robert Chase, Andrea Hart, Sony Agrawal, Paul Ingravallo, John Pichardo, Rong Kong, Bahige Baroudy, Bruce Malcolm, Zhuyan Guo, Andrew Prongay, Vincent Madison, Lisa Broske, Xiaoming Cui, Kuo-Chi Cheng, Yunsheng Hsieh, Jean-Marc Brisson, Danial Prelusky, Walter Korfmacher, Ronald White, Susan Bogdanowich-Knipp, Anastasia Pavlovsky, Prudence Bradley, Anil K. Saksena, Ashit Ganguly, John Piwinski, Viyyoor Girijavallabhan, and F. George Njoroge Article Title: Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue. Article Snippet: Starting from a pentapeptide Hepatitis C virus NS3 protease inhibitor, a number of a-ketoamide inhibitors based on novel dichlorocyclopropylproline P2 core were synthesized and investigated for their HCV NS3 serine protease activity.. The key intermediate 3,4-dichlorocyclopropylproline was obtained through a dichloro carbene insertion to 3,4-dehydroproline.. The size of the molecules was reduced significantly through a series of truncations of the initial pentapeptide. Article Title: Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease. Article Snippet: The hepatitis C virus (HCV) infection is a leading cause of chronic liver disease.. The moderate efficacy along with side effects of the current pegylated interferon and ribavirin combination therapy underscores the need for more effective and safer new treatment.. In an effort to improve upon our current clinical candidate, Boceprevir (SCH 503034), extensive SAR studies were performed on the P3 capping moieties. Article Title: Improved Photoinduced Fluorogenic Alkene-Tetrazole Reaction for Protein Labeling. Article Snippet: Flash chromatography (FC) was carried out using SiliaFlash P60 (0.04−0.063 mm, 230−400 mesh) from Silicycle or Amberlite XAD4 from Sigma-Aldrich. .. Thin layer chromatography (TLC) was performed on glass-backed, precoated Article Title: Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles Article Snippet: Dry solvents were purchased from Aldrich or Acros and used without further purification.Other solvents or reagentswere used as obtained except when otherwise noted. .. Analytical thin layer chromatography (TLC) was performed on Article Title: Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease. Article Snippet: Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, and affects more than 200 million people worldwide.. Although combination therapy of interferon-R and ribavirin is reasonably successful in treating majority of genotypes, its efficacy against the predominant genotype (genotype 1) is moderate at best, with only about 40% of the patients showing sustained virological response.. Herein, the SAR leading to the discovery of a series of ketoamide derived P1-P3 macrocyclic inhibitors that are more potent than the first generation clinical candidate, boceprevir (1, Sch 503034), is discussed. Article Title: A Photo-Enhanced Oxidative Coupling for Site-Specific Protein Labeling via Noncanonical Amino Acid Incorporation. Article Snippet: UN CO RR EC TE D MA NU SC RI PT Genetically encoded noncanonical amino acids (ncAAs) enable site-specific installation of chemical functionalities into proteins, expanding the scope of protein engineering and bioconjugation.. Here we report a photo-enhanced oxidative coupling strategy that leverages a vinyl sulfide-containing ncAA for selective protein labeling.. An ortho-naphthoquinone methide (oNQM) intermediate is generated in situ from a stable precursor under mild oxidative conditions using ferricyanide, and labeling efficiency is markedly enhanced upon 365 nm irradiation. |